DNA methylation

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  • Chemical modification of cytosine to 5-methylcytosine (5mC) by the attachment of a methyl group to the fifth carbon atom of cytosine
  • DNA methylation mainly occurs at CpG sites, i.e. cytosine nucleotides that are followed by a guanine nucleotide
  • CpG sites are underrepresented in the genome since they are ‘mutational hotspots’: 5mC is prone to be deaminated to thymine, resulting in a C->T mutation



See also