Computational biology and genomics
A continuation of the post on the genomic location of pathogenic ClinVar variants. For this post I will use vcfanno to annotate the ClinVar variants with the ExAC VCF file. To get started, download the ExAC VCF file.
I finally found the reason behind the sporadic 500 internal server errors on my blog. It was caused by the iThemes Security plugin, which had modified the .htaccess file in a manner that was causing the errors. I have disabled the plugin and the site seems to be running fine now. I’ve also added HTTPS…
How many pathogenic ClinVar variants are in intergenic regions? I’ll define genomic regions as per this old post. To get started, download the latest ClinVar variants: