Repetitive elements in vertebrate genomes

Updated 2015 February 8th to include some scatter plots of genome size versus repeat content. I was writing about the make up of genomes today and was looking up statistics on repetitive elements in vertebrate genomes. While I could find individual papers with repetitive element statistics for a particular genome, I was unable to find...

Continue Reading

Genomic Regions Enrichment of Annotations Tool

The Genomic Regions Enrichment of Annotations Tool (GREAT) is a tool that allows you to find enriched ontological terms in a set of genomic regions. This talk (running time ~1 hour) gives an overview of the tool. In brief, GREAT is an alternative to gene-centric enrichment tools such as DAVID and uses a binomial test...

Continue Reading

Rett syndrome and piRNAs

Two years ago we were invited to write an article in a Special Issue of the Disease Markers journal, which was dedicated to autism spectrum disorders (ASD) and biomarkers. From Wikipedia, ASD are disorders characterised by social deficits and communication difficulties, stereotyped or repetitive behaviours and interests, and in some cases, cognitive delays.

Continue Reading